For online version with hyperlinks to further information and publications, see:

http://www.who.int/malaria/publications/atoz/9789241549127/en/

As a personal comment, WHO is well recognised for its rigorous approach to guideline development (the process has been greatly improved in the past 10 years), but little is known about the effectiveness of guideline implementation.  I am reminded of the systematic review I circulated on HIFA about an hour ago – almost all the studies identified were in high-income countries. Much more needs to be done to understand and strengthen the assimilation and adaptation of guidelines at national level in low- and middle-income countries.

OVERVIEW

Malaria case management, which consists of prompt diagnosis and effective treatment, remains a vital component of malaria control and elimination strategies. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on new evidence as well as a recommendation on the use of drugs to prevent malaria in high-risk groups.

The core principles underpinning this edition include: early diagnosis and prompt, effective treatment; rational use of antimalarial treatment to ensure that only confirmed malaria cases receive antimalarials; the use of combination therapy in preventing or delaying development of resistance; and appropriate weight-based dosing of antimalarials to ensure prolonged useful therapeutic life and an equal chance of being cured for all patients…

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